Endocrine Abstracts

Diabetes mellitus is one of the greatest health crises of our time. In response to diabetic stress, pancreatic beta-cells undergo a set of profound phenotypical alterations, including dedifferentiation, polyploidisation and hypertrophy, and apoptosis. Although we know that thyroid hormone (TH) signalling controls these phenomena in response to various injuries, little is known about its role in the pathobiology of diabetic pancreas. The aim of this study was to investigate the...

Diabetic nephropathy (DN) and cardiomyopathy (DC) are two major complications of diabetes that account for over two thirds of deaths among diabetic patients. Our previous studies have shown that thyroid hormone (TH) signalling – in addition to its critical role in physiological growth and organ development – plays similar roles in pathological conditions that encompass cellular dedifferentiation, cyto-architectural reorganization and compensatory growth. Though the r...